Past NORC Pilot & Feasibility Studies

Past Pilot & Feasibility studies include:

• Acute regulation of parathyroid hormone by dietary phosphate
• Adipose lipid droplet proteins as markers for lipid overload
• An examination of dietary obesity related phenotypes in the LG/J and SM/J mouse strains
• Angiotensin II links obesity to osteoarthritis pain via macrophages and TRPA1
• Apolipoprotein M attenuates heart failure induced by high-fat feeding
• Brain mapping of hunger and satiety in obese persons
• Bone demineralization in HIV/AIDS patients treated with HAART
• Caloric restriction in an animal model of Multiple Sclerosis
• Caloric restriction, sleep loss, and metabolism
• Calorie restriction and markers of aging in humans
• Characterization of the human specific MGAT3
• Cognitive and fMRI response to insulin resistance treatment
• Control of Intestinal Function by a conserved family of KCNQ-like potassium channels in C. elegans
• Determining the function of a novel adipocyte specific gene, A530016L24Rik
• Development of a novel arteriovenous graft for pancreatic stem cell transplantation
• Diet and acute promyelocytic leukemia
• Dietary prevention of colon cancer
• Dissecting pathways involved in sensing nutrient status and regulating growth using the zebrafish, Danio rerio
• Effect of bariatric surgery on post-prandial tissue-specific glucose uptake
• Effect of liposuction on insulin sensitivity
• Effects of obesity and saturated fatty acids on peri-implantation events
• Endoplasmic reticulum stress in HIV-metabolic syndrome
• Examination of dietary obesity related phenotypes in the LG/J mouse strains
• Facilitative glucose transport and myocardial function
• Fasting induced changes in ischemia and reperfusion injury in the steatotic liver
• Fatty-acid induced central insulin and leptin resistance
• Follicular free fatty acid levels and oocyte quality
• Genetic variants of the fatty acid translocase CD36 in African-Americans
• Genomic and genetic analysis of adipose tissue
• GLUT8, blastocyst nutrition and hyperinsulinemia
• Identification of genes the regulate zinc metabolism and ras-mediated signaling
• Identifying diet-regulated genes that control obesity
• In vivo analysis of the adipocyte S3-12 protein
• In vivo quantitation of intramyocellular lipid content in human calf muscles using chemical shift imaging
• Interactions of fatty acids with RXRá ligand-binding domain
• Lipin 1 in obesity-related fatty liver disease
• Macrophage metabolism regulates insulin resistance and steatohepatitis
• Metabolic and genetic factors in the obesity-inducing effects of antipsychotics
• Metabolic effects of Valproate and antipsychotic therapy
• Metabolic protection and macrophage polarization by eosinophils in mice fed an Omega 3 fatty acid-rich diet
• Metabolic regulation by brown fat PexRAP
• Metabolic regulation by hepatic GLUT8
• Methylation profiling parent-of-origin effects on dietary obesity in mice
• Modulation of lipid metabolism by vesicular trafficking
• Myocardial metabolism in obesity
• Nutrient regulation of islet beta cell survival
• Nutritional fatty acids and rat brain development
• Omega-3 fatty acids and intestinal stem cell survival following injury
• Polycystic ovary syndrome, hyperinsulinemia and embryotoxicity
• Proteoglycan binding and atherogenicity of apoB-48
• Regulation of fatty acid utilization
• Regulation of incretin release by nonnutritive sweeteners in humans
• Regulation of systemic insulin sensitivity by adipose NAMPT
• Retinoids in enteric nervous system development
• Role of adipocyte NAD biosynthesis in immunometabolism
• Role of caveolin in triacylglycerol storage in lipid droplets
• Role of endosomal pathway in metabolic targeting of fatty acids
• Role of the gastrointestinal microbiota in cardiovascular physiology
• Role of PGC-1ß in hepatic metabolism following high sucrose feeding
• Role of transmission of microbiome on impact of maternal obesity on offspring
• Role of vitamin D in cigarette smoke-induced lung disease
• Role of liver fatty acid binding protein in fatty acid uptake and development of hepatic steatosis
• Site-1 protease and the obese ovary
• Systemic regulation of NAD biosynthesis & its effect on glucose metabolism in mammals
• Systematic study of changing lipodomes and novel biomarkers in obesity & diabetes
• Temporal dietary patterns and obesity phenotypes
• The dynamic mechanism of RXR activation
• The metabolic role of lymphatic lipid transport
• The relationship between follicular free fatty acids, oocyte quality and fetal outcome
• The role of extracellular matrix microfibrils in adiposity and metabolic disease
• Uric acid, GLUT9 and beta cell function-their role in the evolution of metabolic syndrome
• Vitamin K, VKORC1 polymorphisms and osteoporotic fractures