Dmitri Samovski, PhD

Research Interests

Research in Dr. Samovski’s laboratory focuses on the molecular and cellular mechanisms that connect adipose tissue biology, lipid signaling, and extracellular vesicle (EV) communication to systemic metabolic health. His group investigates how nutrient excess, obesity, and weight loss remodel lipid-signaling pathways and EV cargo to influence insulin action and metabolic tissue cross-talk. Dr. Samovski’s current research integrates cellular models, advanced EV analysis, multi-omics approaches, and mechanistic human studies to define how adipose-derived EVs impair insulin sensitivity in obesity and how these pathways improve with weight reduction. His laboratory collaborates with clinical research teams to translate basic discoveries into controlled human studies aimed at identifying molecular drivers of insulin resistance and type 2 diabetes. The long-term goal of this research program is to develop EV- and lipid-based biomarkers and therapeutic targets that can support precision approaches to metabolic disease prevention and treatment.

Specialty

Nutritional Science